Supercritical Antisolvent Precipitation of Sotalol Hydrochloride: Influence of Solvent and of Apparatus Design P.Alessi*, I.Kikic, F. Vecchione ̧ T.Gamse
نویسندگان
چکیده
The Supercritical Anti-Solvent precipitation (SAS) technique was invested in order to obtain the precipitation of a beta receptor drug, sotalol hydrochloride, from two different organic solvents (methanol and ethanol). In preliminary studies the solubility of sotalol hydrochloride in CO2 was determined and with the SAS batch apparatus the precipitation pressure for different drug concentration at a given temperature was tested. The following step was to analyse vapour-liquid equilibria (VLE) modifications induced by the presence of the active principle, sotalol hydrochloride, for the binary system CO2ethanol and CO2-methanol at different solute concentration with a variable volume cell. The final step was the precipitation of sotalol hydrochloride with two different designs of semi-continuous SAS apparatus. Scanning Electronic Microscopy (SEM) analysis completed the study in order to determine the role of SAS process parameters (pressure, concentration) and the effect of different solvents on the size and morphology of the drug.
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